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KMID : 1033220240140010037
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Journal of Acute Care Surgery
2024 Volume.14 No. 1 p.37 ~ p.40
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Acquired Factor V Deficiency After Carbapenem Administration: A Case Report
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Park Hye-Jeong
Lee Jee-Yeon
Kim Im-Kyung
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Abstract
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Factor V (FV) deficiency is a coagulation disorder (congenital or acquired). Unlike congenital FVdeficiency, mixing tests for prothrombin time and activated partial thromboplastin time are notcorrected in acquired FV cases. A 79-year-old male was admitted to the intensive care unit after anemergency operation due to gastric ulcer perforation. While receiving antibiotic treatment for septicshock, the coagulation profile began to show prolongation of prothrombin time and activated partialthromboplastin time. FV deficiency (< 1%) following meropenem administration was diagnosed . Thepatient did not show spontaneous bleeding or bleeding tendency. With fresh frozen plasma transfusion,steroid administration, and discontinuation of meropenem, the blood coagulation profile test result wasnormalized 20 days after diagnosis. His follow-up FV level increased to 78.7%. Although abnormalities incoagulation profiles are common in sepsis patients, in our patient, timely recognition and hematologicalconsultation allowed early diagnosis and proper management of FV deficiency.
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KEYWORD
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carbapenem, factor V deficiency, sepsis
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